4-Acetylbutyric Acid

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Catalogue Number	A168440
Chemical Name	4-Acetylbutyric Acid
Synonyms	4-Acetylbutyric Acid; 5-Ketocaproic Acid; 5-Ketohexanoic Acid; 5-Oxocaproic Acid; 5-Oxohexanoic Acid; NSC 5281; γ-Acetylbutyric Acid; δ-Ketocaproic Acid; δ-Ketohexanoic Acid; δ-Oxocaproic Acid
CAS Number	3128-06-1
Molecular Formula	C₆H₁₀O₃
Appearance	Off-White Semi-Solid
Melting Point	N/A
Molecular Weight	130.14
Storage	Refrigerator
Solubility	Chloroform (Slightly), Methanol (Slightly)
Category	Building Blocks; Miscellaneous;
Applications	4-Acetylbutyric Acid is used in the synthesis of selective indomethacin analogues for AKR1C3 inhibition in the treatment of castrate-resistant prostate cancer. Also used to prepare PARP inhibitors for the treatment of cancer as well.
References	Liedtke, A. et al.: J. Med. Chem., 56, 2429 (2013); Zhu, G. et al.: Bioorg. Med. Chem., 20, 4653 (2012);